科研项目:
国家自然科学基金,青年项目,32300055,双环吉玛烯合成酶晶体结构解析及其远端位点调控的催化机制研究,2024.01至2026.12,30万,主持,在研。
中国博士后科学基金,面上项目,2023M742602,香橙烯型倍半萜合酶Agr5的柔性氨基酸残基催化反应中间体羟化的机制研究,2023.11至2024.12,8万,主持,已结题。
企业横向,秸秆生物发酵法用酶系统开发,2023.07至2024.06,20万元,主持,已结题。
浙江省“尖兵”、“领雁”科技计划,2025C01102,基因调控元件工程化设计关键技术与生物制造应用,2025.01至2026.12,900万,参与。
绍兴“名士之乡”英才计划-领军人才创业项目,2024.08至2027.12,200万,参与。
发表文章:
1. Xiaoguang Yan#, Jiahui Zhou#, Jianjun Ge#, Weiguo Li, Dongmei Liang, Warispreet Singh, Gary Black, Shengxin Nie, Jian Liu, Meiqing Sun, Jianjun Qiao*, Meilan Huang*. Computer-informed engineering: A new class I sesquiterpene synthase JeSTS4 for the synthesis of an unusual C10-(S)-bicyclogermacrene. ACS Catalysis. 2022, 12 (7): 4037-4045. (1区Top, IF=13.7)
2. Tingting Niu#, Xiaoguang Yan#, Jingru Wang, Hongjian Song, Yi Cui, Xiangping Cai, Alan Kueichieh Chang, Jianjun Qiao*, Mingzhang Wen*, Jianwei He*. Engineering of Pichia pastoris for the de novo synthesis of the sesquiterpene zealexin A1 from methanol. ACS Sustainable Chemistry & Engineering. 2024, 12 (34): 12786-12794. (1区Top, IF=8.4)
3. Yukun Li, Ran Li, Jianjun Ge, Shengxin Nie, Ruiqi Chen, Xiaoguang Yan*, Jianjun Qiao*. Comprehensive engineering strategies for heterologous production of zealexin a1 in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2024, 72 (34): 19071-19080. (1区Top, IF=6.1)
4. Shengxin Nie#, Shengli Wang#, Ruiqi Chen, Mingyue Ge, Xiaoguang Yan*, Jianjun Qiao*. Catalytic mechanism and heterologous biosynthesis application of Sesquiterpene Synthases. Journal of Agricultural and Food Chemistry, 2024, 72 (13): 6871-6888. (1区Top, IF=6.1)
5. Xiaoguang Yan, Ran Ye, Ye Chen*. Blasting extrusion processing: the increase of soluble dietary fiber content and extraction of soluble-fiber polysaccharides from wheat bran. Food Chemistry, 2015, 180: 106-115. (1区Top, IF=9.8)
6. Weiguo Li#, Xiaoguang Yan#, Yuting Zhang, Dongmei Liang, Qinggele Caiyin, Jianjun Qiao*. Characterization of trans-nerolidol synthase from Celastrus angulatus Maxim and production of trans-nerolidol in engineered Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2021, 69 (7): 2236-2244. (1区Top, IF=6.1)
7. Shengxin Nie, Ruiqi Chen, Mingyue Ge, Yu Qu, Xiaofeng Liu, Chaofeng Ruan, Xiaoguang Yan*, Jianjun Qiao*.Biosynthesis of irregular monoterpene lavandulol in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology.2025,10:1267–1274. (1区Top, IF=4.4)
8. Xiaoguang Yan#, Sichone Daniel David#, Guangzhao Du, Weiguo Li, Dongmei Liang, Shengxin Nie, Mingyue Ge, Chen Wang, Jianjun Qiao, Yanni Li*, Qinggele Caiyin*. Biological properties of sandalwood oil and microbial synthesis of its major sesquiterpenoids. Biomolecules 2024, 14 (8), 971. (2区, IF=5.5)
9. Xiaoguang Yan#, Jiaqi Lin#, Ziming Liu, Sichone Daniel David, Dongmei Liang, Shengxin Nie, Mingyue Ge, Zhaohui Xue, Weiguo Li*, Jianjun Qiao*. The recent progress of tricyclic aromadendrene-type sesquiterpenoids: Biological activities and biosynthesis. Biomolecules, 2024, 14 (9), 1133. (2区, IF=5.5)